BDBM50420736 CHEMBL2087483

SMILES C[C@H]1CN(Cc2cn3cc(nc(N4CCOCC4)c3n2)-c2cnc(N)nc2)CCN1S(C)(=O)=O

InChI Key InChIKey=AQWQIQDUUYUMGY-HNNXBMFYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50420736   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50420736(CHEMBL2087483)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human PI3Kalpha (p110alpha/p85alpha) by ADP accumulation based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50420736(CHEMBL2087483)
Affinity DataKi:  14.7nMAssay Description:Inhibition of human PI3Kdelta (p110delta/p85alpha) by ADP accumulation based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50420736(CHEMBL2087483)
Affinity DataKi:  124nMAssay Description:Inhibition of human PI3Kgamma by ADP accumulation based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50420736(CHEMBL2087483)
Affinity DataIC50:  120nMAssay Description:Inhibition of PI3Kalpha in human U2OS cells assessed as inhibition of AKT Ser 473 phosphorylation by Western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50420736(CHEMBL2087483)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human PI3Kalpha (p110alpha/p85alpha) by ADP accumulation based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed