BDBM50460538 CHEMBL4224767

SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(ccc3F)C3CC3)c3OC(C)(C)Cc3c2[nH]1

InChI Key InChIKey=MOICVXMOMQNYIF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50460538   

TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50460538(CHEMBL4224767)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50460538(CHEMBL4224767)
Affinity DataIC50: 447nMAssay Description:Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed