BDBM50463221 CHEMBL4251253

SMILES FC(F)(F)Oc1ccc(Nc2nc(nc(n2)N2CCOCC2)C#N)cc1

InChI Key InChIKey=DGNCYEKXMJMVGO-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50463221   

TargetCathepsin S(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50463221(CHEMBL4251253)
Affinity DataKi:  2nMAssay Description:Inhibition of human cathepsin S using Z-LR-AMC as substrate after 30 mins by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCathepsin S(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50463221(CHEMBL4251253)
Affinity DataIC50: 3nMAssay Description:Inhibition of human cathepsin S using Z-LR-AMC as substrate after 30 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCathepsin K(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50463221(CHEMBL4251253)
Affinity DataKi:  700nMAssay Description:Inhibition of human cathepsin K using Z-Phe-Arg-AMC as substrate after 30 mins by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCathepsin K(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50463221(CHEMBL4251253)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cathepsin K using Z-Phe-Arg-AMC as substrate after 30 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCathepsin B(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50463221(CHEMBL4251253)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human cathepsin B using Z-Phe-Arg-AMC as substrate after 30 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCathepsin B(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50463221(CHEMBL4251253)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human cathepsin B using Z-Phe-Arg-AMC as substrate after 30 mins by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed