BDBM50468124 CHEMBL4288109::US11247985, Table 3.45

SMILES C(Cc1ccccc1)NC1CCN(CC1)c1cccc(c1)-c1cc2ccccc2[nH]1

InChI Key InChIKey=FQRRWMODJHYCEH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50468124   

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh Chemical Diversity Center

Curated by ChEMBL
LigandPNGBDBM50468124(CHEMBL4288109 | US11247985, Table 3.45)
Affinity DataIC50: 2.61E+3nMAssay Description:Inhibition of recombinant full length human p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2 (DE3) using 100 uM ATP as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh Chemical Diversity Center

Curated by ChEMBL
LigandPNGBDBM50468124(CHEMBL4288109 | US11247985, Table 3.45)
Affinity DataIC50: 2.70E+3nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent