BDBM50478401 4-O-Demethylmanassantin B

SMILES COc1cc(ccc1O)[C@@H](O)[C@@H](C)Oc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)[C@H](O)c2ccc3OCOc3c2)c(OC)c1

InChI Key InChIKey=WQSGIPAMJXWYGZ-NPIUFYBCSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50478401   

TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50478401(4-O-Demethylmanassantin B)
Affinity DataIC50:  30nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed