BDBM50483950 CHEMBL1797106

SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nnc(N[C@@H](C)c2ccc(F)cc2)c(C)c1C

InChI Key InChIKey=PTPDKUBOKAKOCS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50483950   

TargetPresenilin-1(Human)
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483950(CHEMBL1797106)
Affinity DataIC50: 316nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483950(CHEMBL1797106)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed