BDBM50499299 CHEMBL3735207

SMILES CC(C)n1nc(C#Cc2cccc(c2)C(=O)Nc2cccc(c2)C(F)(F)F)c2c(N)ncnc12

InChI Key InChIKey=AUCLAHKYXYWIBN-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50499299   

TargetTyrosine-protein kinase ABL1(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50499299(CHEMBL3735207)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human wild-type Abl after 30 mins by phosphocellulose paper disk assay using 0.1 mM EAIYAAPFAKKK peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50499299(CHEMBL3735207)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Abl T315I mutant (unknown origin) after 30 mins by phosphocellulose paper disk assay using 0.1 mM EAIYAAPFAKKK peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50499299(CHEMBL3735207)
Affinity DataEC50:  3nMAssay Description:Inhibition of wild-type Bcr-Abl autophosphorylation (unknown origin) expressed in mouse BA/F3 cells for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50499299(CHEMBL3735207)
Affinity DataEC50:  25nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) autophosphorylation expressed in mouse BA/F3 cells for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed