BDBM50502501 CHEMBL4475046

SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(NCC(OC)OC)ncnc12)[C@H](O)c1ccc(Cl)cc1

InChI Key InChIKey=SFXBSODSUAZMSY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502501   

LigandPNGBDBM50502501(CHEMBL4475046)
Affinity DataIC50: 177nMAssay Description:Inhibition of human recombinant PRMT5/MEP50 expressed in baculovirus infected High-five cells using histone 4 peptide as substrate in presence of [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502501(CHEMBL4475046)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRMT5 in human Granta-519 assessed as reduction in sDMA production incubated for 3 days by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed