BDBM50514262 CHEMBL4576031

SMILES C[C@H]1OC2(CCN(CCc3ccccc3F)CC2)CN(C1=O)c1cnccc1C(F)(F)F

InChI Key InChIKey=INCPDVXLHDEOLM-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50514262   

TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514262(CHEMBL4576031)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514262(CHEMBL4576031)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human MOR expressed in CHOK1 cells assessed as stimulation of cAMP accumulation incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514262(CHEMBL4576031)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor expressed in HEK293 membranes incubated for 120 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514262(CHEMBL4576031)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed