BDBM50517807 CHEMBL4570374

SMILES Brc1cc(NCc2cccc3nonc23)c2cn[nH]c2c1

InChI Key InChIKey=PEQNQOXHKPQOQM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50517807   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Phenikaa University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 740nMAssay Description:Inhibition of human recombinant IDO1 incubated for 1 hr by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Phenikaa University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 740nMAssay Description:Inhibition of human IDO1 expressed in Escherichia coli using L-tryptophan as substrate after 1 hr by UV absorption analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Phenikaa University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in L-kynurenine level after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Phenikaa University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of human recombinant TDO incubated for 1 hr by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Phenikaa University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of human TDO expressed in Escherichia coli at using L-tryptophan as substrate after 1 hr by UV absorption analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Phenikaa University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 7.54E+3nMAssay Description:Inhibition of human TDO expressed in human A172 assessed as reduction in kynurenine formation using L-tryptophan as substrate after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed