BDBM50521398 CHEMBL4450464

SMILES C[C@@H](Nc1nc2n(ncc2c(=O)[nH]1)C1CCCC1)C(=O)N1CC[C@@H](F)C1

InChI Key InChIKey=HOQGZKUBNCAZBE-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521398   

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University

Curated by ChEMBL

LigandBDBM50521398(CHEMBL4450464)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Sun Yat-Sen University

Curated by ChEMBL

LigandBDBM50521398(CHEMBL4450464)Copy SMILESCopy InChI

Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL