BDBM50522629 CHEMBL4449897

SMILES COc1c(ccc2[nH]c(cc12)-c1nc2[C@H](OCCn2n1)c1ccccc1C(F)(F)F)C#N

InChI Key InChIKey=NFZWXCQYERVPEI-LJQANCHMSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50522629   

TargetPresenilin-1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50522629(CHEMBL4449897)
Affinity DataIC50:  603nMAssay Description:Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed