BDBM50523632 CHEMBL4454122

SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H](CN2CC(F)(F)CC22CCNCC2)[C@@H](O)[C@H]1O

InChI Key InChIKey=SUWBCGVROXCBGR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50523632   

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523632(CHEMBL4454122)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of PRMT5 (unknown origin) assessed as reduction in SAH formation using histone H2A and SAM incubated for 60 mins by high throughput mass s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523632(CHEMBL4454122)
Affinity DataIC50: 51nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production incubated for 48 hrs by immunohistochemistry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed