BDBM50523633 CHEMBL4554624

SMILES Nc1ncnc2n(ccc12)[C@@H]1C[C@H](Sc2ccc(Cl)cc2)[C@@H](O)[C@H]1O

InChI Key InChIKey=MHLOCKTYXIORPC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50523633   

LigandPNGBDBM50523633(CHEMBL4554624)
Affinity DataIC50: 26nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523633(CHEMBL4554624)
Affinity DataIC50: 63nMAssay Description:Inhibition of PRMT5 in human Granta-519 assessed as reduction in sDMA production after 3 days by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed