BDBM50523636 CHEMBL4457371

SMILES [H][C@@]1(C[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)[C@H](O)c1ccc(F)c(F)c1

InChI Key InChIKey=DNDCXYZRSRFLRY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50523636   

LigandPNGBDBM50523636(CHEMBL4457371)
Affinity DataIC50: 2nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523636(CHEMBL4457371)
Affinity DataIC50: 134nMAssay Description:Inhibition of PRMT5 in human Granta-519 assessed as reduction in sDMA production after 3 days by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed