BDBM50523651 CHEMBL4579108::US10709709, Example 90

SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(F)(F)F)[C@@H](O)[C@H]1O

InChI Key InChIKey=QDHALPIIHPGYSX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50523651   

TargetProtein arginine N-methyltransferase 5(Human)
Pfizer

US Patent
LigandPNGBDBM50523651(CHEMBL4579108 | US10709709, Example 90)
Affinity DataIC50: 2nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Pfizer

US Patent
LigandPNGBDBM50523651(CHEMBL4579108 | US10709709, Example 90)
Affinity DataIC50: 2nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed