BDBM50539124 CHEMBL4640647

SMILES OB(O)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)cc1

InChI Key InChIKey=LMWZRTIJZLQQJP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50539124   

TargetTyrosine-protein kinase JAK3(Human)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50539124(CHEMBL4640647)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system using Ulight-Poly GT as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50539124(CHEMBL4640647)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50539124(CHEMBL4640647)
Affinity DataIC50: 892nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using Ulight-Poly GT as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50539124(CHEMBL4640647)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK1 (850 to 1154 residues) expressed in baculovirus expression system using Ulight-Poly GT as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50539124(CHEMBL4640647)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TYK2 (871 to 1187 residues) expressed in baculovirus expression system using Ulight-Poly GT as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed