BDBM50539745 CHEMBL4642347

SMILES CC(C)c1ccc2[nH]ncc2c1N1CCc2c(C1)nc(OC[C@@H]1CCCN1C)nc2N1CCN(CC1)C(=O)C=C

InChI Key InChIKey=PQYZPEBTMDDKNX-NRFANRHFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50539745   

TargetGTPase KRas(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539745(CHEMBL4642347)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed