BDBM50539759 CHEMBL4646899

SMILES CCc1cccc2cccc(N3CCc4c(C3)nc(OC[C@@H]3CCCN3C)nc4N3CCN([C@@H](CC#N)C3)C(=O)C=C)c12

InChI Key InChIKey=QHSWWHCSXWHQQP-SVBPBHIXSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50539759   

TargetGTPase KRas(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539759(CHEMBL4646899)
Affinity DataIC50:  6nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed