BDBM50544503 CHEMBL4644158

SMILES Fc1ccc(CNC(=O)[C@@H]2Cc3c(CN2)[nH]c2ccccc32)cc1

InChI Key InChIKey=LRVUOCABDZPTEL-KRWDZBQOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544503   

TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544503(CHEMBL4644158)
Affinity DataIC50:  900nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544503(CHEMBL4644158)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human Nav1.7 expressed in HEK293 cells assessed as inhibition of veratridine-induced increase in calcium flux by FLIPR dye bas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544503(CHEMBL4644158)
Affinity DataIC50:  37nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed