BDBM50544866 CHEMBL4643904::US11292781, Compound T146
SMILES [H][C@]12CCc3c(nc(nc3[C@]1(C)C=C(C#N)C(=O)[C@@H]2CCC)-c1ccnc(c1)C1CC1)-c1ccccc1F
InChI Key InChIKey=CZPFBLHFGKUTTQ-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50544866
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inverse agonist activity at full-length human RORgammat C285S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at human full-length RORgammaT expressed in Jurkat cells co-transfected with 5 copies of ROR response element after 18 hrs b...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inverse agonist activity at full-length human RORgammat C345S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inverse agonist activity at wild type full-length human RORgammat co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inverse agonist activity at full-length human RORgammat C278S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:The RORγ assay system was purchased from Indigo Biosciences. This nuclear receptor assay utilizes a human cell line that has been engineered to ...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at full-length human RORgammat C393S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at full-length human RORgammat C366S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inverse agonist activity at full-length human RORgammat C455S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inverse agonist activity at full-length human RORgammat C320S mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inverse agonist activity at full-length human RORgammat C320A mutant co-transfected with ROR response element by luciferase based reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair