BDBM50547335 CHEMBL3741275

SMILES CN(CCN(C)C(=O)c1coc2ccccc2c1=O)C(=O)c1cn(c2ccccc12)S(=O)(=O)c1cccc(c1)[N+]([O-])=O

InChI Key InChIKey=CASABOSNGORYTE-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547335   

TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Agricultural University Of Athens

Curated by ChEMBL
LigandPNGBDBM50547335(CHEMBL3741275)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to GST-fused human RANKL extracellular domain (Lys159 to Asp317 residues) expressed in Escherichia coli BL21(DE3) pLysS by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 11(Homo sapiens)
Agricultural University Of Athens

Curated by ChEMBL
LigandPNGBDBM50547335(CHEMBL3741275)
Affinity DataIC50:  5.07E+3nMAssay Description:Inhibition of human RANKL-induced osteoclastogenesis in RANKL cultured mouse bone marrow cells assessed as reduction in RANKL/M-CSF-induced TRAP acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed