BDBM50553500 CHEMBL4800498

SMILES CNC(=O)c1nc(C)n2ccc(Nc3nccc(n3)-n3cc(CN(C)C)cn3)cc12

InChI Key InChIKey=PLXRPQJOIKHDDA-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50553500   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50553500(CHEMBL4800498)Copy SMILESCopy InChI

Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human ERG assessed as tail current by plate-based planar patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50553500(CHEMBL4800498)Copy SMILESCopy InChI

Affinity DataIC50:  0.240nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI