BDBM50568615 CHEMBL4862573

SMILES COc1cccc(c1)-c1cn2c(nc3cc(F)c(F)cc23)c(N)n1

InChI Key InChIKey=IWEHFIDUVARCKN-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50568615   

TargetAdenosine receptor A2a(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50568615(CHEMBL4862573)
Affinity DataIC50: 27nMAssay Description:Displacement of [3H]-ZM241385 from human recombinant A2A receptor expressed in human HEK293 cell membrane preincubated for 5 mins and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50568615(CHEMBL4862573)
Affinity DataIC50: 77nMAssay Description:Antagonist activity at human A2A expressed in human HEK293 cells assessed as reduction in cAMP production preincubated for 10 mins followed by NECA s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50568615(CHEMBL4862573)
Affinity DataIC50: 460nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO-K1 cell membrane preincubated for 5 mins followed measured after 50 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50568615(CHEMBL4862573)
Affinity DataEC50:  524nMAssay Description:Antagonist activity at human A2A receptor on T-cells assessed as increase of IL-2 production preincubated for 1 hr followed by addition of T-cell act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed