BDBM50573594 CHEMBL4849606

SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(=O)NCCCCCCC(=O)NO)ncc1Cl

InChI Key InChIKey=RBYNLDMNBXNZMS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50573594   

TargetALK tyrosine kinase receptor(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573594(CHEMBL4849606)
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573594(CHEMBL4849606)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573594(CHEMBL4849606)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of ALK (unknown origin) preincubated for 10 mins followed by addition of substrate and ATP for 25 mins by caliper EZ reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573594(CHEMBL4849606)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573594(CHEMBL4849606)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Ac-peptide-AMC as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573594(CHEMBL4849606)
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed