BDBM50587246 CHEMBL5083295

SMILES FC(F)(F)c1cc(NC(=O)[C@H]2C[C@H](CN2)NC(=O)c2cccc(c2)-c2cncc(c2)C(=O)NC2CC2)ccc1Cl

InChI Key InChIKey=RJPMIRYHUNJIGK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50587246   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50587246(CHEMBL5083295)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50587246(CHEMBL5083295)
Affinity DataIC50: 2.66E+4nMAssay Description:Inhibition of wild type Bcr-Abl T315I mutant (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed