BDBM50591522 CHEMBL4473010

SMILES CC(C)(C)CNC(=S)Nc1ccc2N(Cc3ccc(F)cc3)CCc2c1

InChI Key InChIKey=KXQYKIJQWCBWAP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50591522   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591522(CHEMBL4473010)
Affinity DataIC50:  450nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591522(CHEMBL4473010)
Affinity DataIC50:  1.39E+3nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591522(CHEMBL4473010)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed