BDBM50603179 CHEMBL5191350

SMILES CN(CCCOc1cc(NCc2ccc(\C=C\C(=O)NO)cc2)ccc1Cl)CC#C

InChI Key InChIKey=JWIRZQYHZOIRPQ-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50603179   

TargetAmine oxidase [flavin-containing] A(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50603179(CHEMBL5191350)
Affinity DataIC50: 4nMAssay Description:Inhibition of MAO-A (unknown origin) expressed in mouse GL26 cells using 14C 5-hydroxytryptamine as substrate pre-incubated for 20 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50603179(CHEMBL5191350)
Affinity DataIC50: 80nMAssay Description:Inhibition of human HDAC8 (379 to 382 residues) using RHKKAcKAc-AMC fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50603179(CHEMBL5191350)
Affinity DataIC50: 100nMAssay Description:Inhibition of human HDAC6 (379 to 382 residues) using RHKKAc fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50603179(CHEMBL5191350)
Affinity DataIC50: 510nMAssay Description:Inhibition of human HDAC1 (379 to 382 residues) using RHKKAc-AMC fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50603179(CHEMBL5191350)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of human HDAC2 (379 to 382 residues) using RHKKAc-AMC fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50603179(CHEMBL5191350)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of human LSD1 assessed as demethylase activity of LSD1 using Histone H3(1-21)K4me2 peptide as substrate incubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed