BDBM50609808 CHEMBL5287237

SMILES CCCCOc1ccc(cc1NC(=O)c1nnn(c1C)-c1c(OC)cccc1OC)C(C)(C)C

InChI Key InChIKey=NICLOWVEPUBBIS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50609808   

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50609808(CHEMBL5287237)
Affinity DataIC50: 93nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50609808(CHEMBL5287237)
Affinity DataEC50:  240nMAssay Description:Agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as transcriptional activat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50609808(CHEMBL5287237)
Affinity DataIC50: 1.44E+3nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed