BDBM50630362 CHEMBL5427803

SMILES Nc1ccc2c(OCCNCCOc3cccc4nc(N)ccc34)cccc2n1

InChI Key InChIKey=QGOSCGUPSZLNPQ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50630362   

TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630362(CHEMBL5427803)
Affinity DataKi:  310nMAssay Description:Inhibition of Cy5-labeled p22phox (149 to 162 residues) probe binding to His-tag cleaved human p47phox (151 to 386 residues) expressed in Escherichia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630362(CHEMBL5427803)
Affinity DataKi:  420nMAssay Description:Inhibition of Cy5-labeled p22phox (149 to 162 residues) probe binding to His-tagged human p47phox (151 to 286 residues) expressed in Escherichia coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630362(CHEMBL5427803)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of NOX-2 dependent superoxide generation in PMA-differentiated human PLB-985 cells incubated for 1 hr by WST-1 based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed