BDBM523032 US11161854, Example 2.6-1::US11161854, Example 2.6-2

SMILES CNc1nc(cc(n1)-n1ncc2ccc(cc12)C1(CC11CC1)C#N)N1CC[C@H](C1)C(C)(C)O

InChI Key InChIKey=MBBSFAFTWZGWGM-YDONVPIESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 523032   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1-1200,1251-2527,G2019S](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM523032(US11161854, Example 2.6-1 | US11161854, Example 2....)
Affinity DataIC50:  0.800nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1-1200,1251-2527,G2019S](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM523032(US11161854, Example 2.6-1 | US11161854, Example 2....)
Affinity DataIC50:  0.800nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent