BDBM523109 US11161854, Example 5.3-1::US11161854, Example 5.3-2

SMILES CC(C)(O)[C@@H]1CCN(C1)c1cc(ncn1)-n1ncc2cnc(cc12)C1(CC11CC1)C#N

InChI Key InChIKey=BKDSPJFZLFEVII-ADRQNKRLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 523109   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1-1200,1251-2527,G2019S](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM523109(US11161854, Example 5.3-1 | US11161854, Example 5....)
Affinity DataIC50:  0.700nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1-1200,1251-2527,G2019S](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM523109(US11161854, Example 5.3-1 | US11161854, Example 5....)
Affinity DataIC50:  7.5nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent