BDBM531299 US11208399, Example 54

SMILES Cc1cc(nnc1N[C@H]1C[C@@](C)(O)C1)-c1c(C)cc(cc1O)C(F)(F)F

InChI Key InChIKey=MXHYWYQAZPVXME-LAUQKZGBSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531299   

TargetTumor necrosis factor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM531299(US11208399, Example 54)
Affinity DataIC50:  3.50E+4nMAssay Description:Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM531299(US11208399, Example 54)
Affinity DataIC50:  11.8nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent