BDBM559915 6-Tert-butyl-N-{4-methyl-3-[5- (morpholin-4-yl)-6-(prop-1-yn-1- yl)pyridin-3-yl]phenyl}pyrimidine-4- carboxamide::US11377431, Example 27

SMILES CC#Cc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cc(ncn2)C(C)(C)C)ccc1C

InChI Key InChIKey=CJISSDKVUUCORY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 559915   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM559915(US11377431, Example 27 | 6-Tert-butyl-N-{4-methyl-...)
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of the BRA and RAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test ...More data for this Ligand-Target Pair
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Date in BDB:
10/5/2022
Entry Details
US Patent