BDBM578526 3-(5-chloro-3- (difluoromethyl)py- ridin-2-yl)-3- methoxy-5,5- dimethyl-6- oxocyclohex-1- enecarbonitrile (Enantiomer A)::US11479539, Compound 158::US11479539, Compound 206::US11479539, Compound 45

SMILES COC1(CC(C)(C)C(=O)C(=C1)C#N)c1ncc(Cl)cc1C(F)F

InChI Key InChIKey=DIUGUFDMFYLOEO-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 578526   

Targethek293 luciferase(Human immunodeficiency virus type 1 group M subtyp...)
Medimmune

US Patent
LigandPNGBDBM578526(3-(5-chloro-3- (difluoromethyl)py- ridin-2-yl)-3- ...)
Affinity DataEC50:  21nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targethek293 luciferase(Human immunodeficiency virus type 1 group M subtyp...)
Medimmune

US Patent
LigandPNGBDBM578526(3-(5-chloro-3- (difluoromethyl)py- ridin-2-yl)-3- ...)
Affinity DataEC50:  28nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targethek293 luciferase(Human immunodeficiency virus type 1 group M subtyp...)
Medimmune

US Patent
LigandPNGBDBM578526(3-(5-chloro-3- (difluoromethyl)py- ridin-2-yl)-3- ...)
Affinity DataEC50:  159nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent