BDBM578539 7-methoxy-4-7- (4-methyl-1,3- thiazol-2-yl)-4- oxospiro[2.5]oct- 5-ene-5- carbonitrile (Enantiomer A)::US11479539, Compound 140::US11479539, Compound 59

SMILES COC1(CC2(CC2)C(=O)C(=C1)C#N)c1nc(C)cs1

InChI Key InChIKey=SFYUNAHVSUWDJA-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 578539   

Targethek293 luciferase(Human immunodeficiency virus type 1 group M subtyp...)
Medimmune

US Patent
LigandPNGBDBM578539(7-methoxy-4-7- (4-methyl-1,3- thiazol-2-yl)-4- oxo...)
Affinity DataEC50:  261nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targethek293 luciferase(Human immunodeficiency virus type 1 group M subtyp...)
Medimmune

US Patent
LigandPNGBDBM578539(7-methoxy-4-7- (4-methyl-1,3- thiazol-2-yl)-4- oxo...)
Affinity DataEC50:  140nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent