BDBM606103 US11684616, Example 6a::US11684616, Example 6b

SMILES COC[C@@H](N)c1nc(cc2C(=O)N(Cc12)c1cccc(n1)-c1nnc2CC[C@H](C)n12)C1(C)CC1

InChI Key InChIKey=HFTWWDARPWZARK-WMLDXEAASA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 606103   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM606103(US11684616, Example 6a | US11684616, Example 6b)
Affinity DataKi:  0.190nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM606103(US11684616, Example 6a | US11684616, Example 6b)
Affinity DataKi:  6.10nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM606103(US11684616, Example 6a | US11684616, Example 6b)
Affinity DataIC50:  48.6nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM606103(US11684616, Example 6a | US11684616, Example 6b)
Affinity DataIC50:  942nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent