BDBM610489 N-(4-Ethoxypyrimidin-5-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 37

SMILES CCOc1ncncc1NC(=O)c1ccnn2cc(nc12)-c1ccccc1

InChI Key InChIKey=SHJYLIJHYBXPEO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 610489   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610489(N-(4-Ethoxypyrimidin-5-yl)-2-phenylimidazo[1,2-b]p...)
Affinity DataIC50:  5.30nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610489(N-(4-Ethoxypyrimidin-5-yl)-2-phenylimidazo[1,2-b]p...)
Affinity DataIC50:  620nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610489(N-(4-Ethoxypyrimidin-5-yl)-2-phenylimidazo[1,2-b]p...)
Affinity DataIC50:  1nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent