BDBM626334 2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoic acid::US11787775, Compound 19

SMILES CC(F)(F)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12

InChI Key InChIKey=LWXKEPIDUIQNKC-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626334   

TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataIC50:  50nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-4(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataIC50:  350nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-5(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataIC50:  6.40E+3nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataEC50:  230nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataEC50:  40nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataEC50:  190nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataEC50:  1.50E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataIC50:  110nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent