BDBM626335 2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d]pyrimidin-2- yl]amino]methyl]prop-2-enoic acid::US11787775, Compound 20

SMILES CC(C)c1ccc(cc1)-c1nc(NCC(=C)C(O)=O)nc2CCOc12

InChI Key InChIKey=NWGUMSQMFYGSDM-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626335   

TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataIC50:  200nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-4(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataIC50:  70nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-5(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataIC50:  3.80E+3nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataEC50:  40nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataEC50:  150nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataEC50:  40nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataIC50:  20nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent