BDBM626360 2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enamide::US11787775, Compound 44

SMILES NC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=NBEOCCGZJYARJJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626360   

TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  110nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-4(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  40nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-5(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  320nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  240nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  70nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  140nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent