BDBM649674 N-(2-((4-((3′-(3-(4-(((2-acetylaminoethyl)amino) methyl)-1H-1,2,3-triazole-1-yl)propoxy)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)methoxy)-5-chloro-2-((5-cyanopyridine-3-yl)methoxy) benzyl)amino)ethyl)acetamide::US20240043392, Compound II-3

SMILES CC(=O)NCCNCc1cn(CCCOc2cccc(c2C)-c2cccc(COc3cc(OCc4cncc(c4)C#N)c(CNCCNC(C)=O)cc3Cl)c2C)nn1

InChI Key InChIKey=WHMBBEGUPSDHOU-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 649674   

TargetProgrammed cell death 1 ligand 1(Human)
Xi'An Xinton Pharmaceutcal Research

US Patent
LigandPNGBDBM649674(N-(2-((4-((3′-(3-(4-(((2-acetylaminoethyl)am...)
Affinity DataKd:  50nMAssay Description:The test compound was dissolved in DMSO to make a stock solution with a final concentration of 10 mM, then diluted to 1× with 1.05× PBS-P+, and then ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
Xi'An Xinton Pharmaceutcal Research

US Patent
LigandPNGBDBM649674(N-(2-((4-((3′-(3-(4-(((2-acetylaminoethyl)am...)
Affinity DataIC50: 55nMAssay Description:A negative control, a positive control and drug administration groups were set up, with two duplicate wells in each group. For the positive control g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent