BDBM757725 US12358911, Compound 10

SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(OCCN(C)c4ncc(C(=O)NO)cn4)cn3)nc2n(C2CCCC2)c1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 757725   

TargetHistone deacetylase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757725(US12358911, Compound 10)
Affinity DataIC50: 5nMAssay Description:The inhibitory effect of compounds on HDAC-1 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757725(US12358911, Compound 10)
Affinity DataIC50: 17.5nMAssay Description:Method 1: In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757725(US12358911, Compound 10)
Affinity DataIC50: 30nMAssay Description:The inhibitory effect of compounds on HDAC-1 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757725(US12358911, Compound 10)
Affinity DataIC50: 37.5nMAssay Description:Method 1: In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757725(US12358911, Compound 10)
Affinity DataIC50: 1.00E+4nMAssay Description:Method 1: In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent