BDBM765610 (R)-7-cyano-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-(isopropylamino) benzo[5,6][1,4]dioxino[2,3-b]pyridine-3-carboxamide (1) and (R)-8-cyano-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-(isopropylamino)benzo[5,6][1,4]dioxino[2,3-b]pyridine-3-carboxamide (2)::US12391702, Example 2

SMILES CC(C)Nc1c(C(=O)NC[C@@H](F)C(C)(C)O)cnc2c1Oc1ccc(C#N)cc1O2

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 765610   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM765610((R)-7-cyano-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4...)
Affinity DataIC50: 8.5nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substrates (fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent