BDBM86616 Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 22

SMILES COc1cc(Nc2ncc3N(C)C(=O)c4ccccc4N(C)c3n2)ccc1C(=O)N1CCN(O)CC1

InChI Key InChIKey=RWCPLVNQNAADEI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 86616   

TargetAurora kinase A(Human)
Harvard Medical School

LigandPNGBDBM86616(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50: 2.60nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

LigandPNGBDBM86616(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50: 24.2nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2012
Entry Details Article
PubMed