BDBM50015607 (E)-1-(2-hydroxyphenyl)-3-(2-hydroxyphenyl)-2-propen-1-one (9)::CHEMBL150755::D-501

SMILES Oc1ccccc1\C=C\C(=O)c1ccccc1O

InChI Key InChIKey=KSHCTKZLHCSARH-MDZDMXLPSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50015607   

TargetBeta-secretase 1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences

LigandPNGBDBM50015607((E)-1-(2-hydroxyphenyl)-3-(2-hydroxyphenyl)-2-prop...)
Affinity DataIC50: >6.00E+4nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50015607((E)-1-(2-hydroxyphenyl)-3-(2-hydroxyphenyl)-2-prop...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50015607((E)-1-(2-hydroxyphenyl)-3-(2-hydroxyphenyl)-2-prop...)
Affinity DataIC50:  8.74E+4nMAssay Description:Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50015607((E)-1-(2-hydroxyphenyl)-3-(2-hydroxyphenyl)-2-prop...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of BChE (unknown origin) using BCh iodide as substrate preincubated for 15 mins prior to substrate addition measured after 10 mins by Ellm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed