BDBM10095 (3Z)-5-fluoro-3-[(3-methoxy-1H-pyrrol-2-yl)methylidene]-4-[3-(methylamino)prop-1-yn-1-yl]-2,3-dihydro-1H-indol-2-one::4-alkynyl oxindole 7a::ROCHE screening, 71

SMILES CNCC#Cc1c2\C(=C\c3[nH]ccc3OC)C(=O)Nc2ccc1F

InChI Key InChIKey=QMIDZOGAPGBZSC-BENRWUELSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 10095   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM10095((3Z)-5-fluoro-3-[(3-methoxy-1H-pyrrol-2-yl)methyli...)
Affinity DataIC50:  52nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM10095((3Z)-5-fluoro-3-[(3-methoxy-1H-pyrrol-2-yl)methyli...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed using a recombinant human cyclin E-CDK2 complex. The enzyme was assayed with substrate in the presence of 1uM ATP/[gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed