BDBM119812 US20240034730, Compound ASLAN003::US8691852, 20
SMILES COc1cccc(c1)-c1cc(F)c(Nc2ncccc2C(O)=O)c(F)c1
InChI Key InChIKey=OMPATGZMNFWVOH-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 119812
Affinity DataIC50: 15nMpH: 8.0Assay Description:DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of Homo sapiens (human) dehydroorotate dihydrogenase using 2,6-dichlorophenol-indophenol as substrate after 10 min by spectrophotometric a...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair