BDBM120665 Roche-Dataset for PDE10A, Compound 895::US8703768, 266

SMILES CNC(=O)c1c(cnn1C)NC(=O)c2c(ncc(n2)[C@H]3CCOC3)Nc4cncnc4

InChI Key InChIKey=RSBKLGMFVRXKKC-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 120665   

LigandPNGBDBM120665(US8703768, 266 | Roche-Dataset for PDE10A, Compoun...)
Affinity DataIC50: 12nMAssay Description:PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM120665(US8703768, 266 | Roche-Dataset for PDE10A, Compoun...)
Affinity DataIC50: 12nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)