BDBM130419 US8822505, 21::US8822505, 23::US8822505, 24

SMILES CC(C)(C)OC(=O)N1CCC1(C(=O)N1C[C@@H](C[C@H]1C(=O)NC1(CC1)C#N)S(=O)(=O)c1ccc(F)cc1Cl)c1ncc(Cl)cc1F

InChI Key InChIKey=XYMLZPAPBAMTAT-VGEZZCLVSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 130419   

TargetProcathepsin L(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM130419(US8822505, 21 | US8822505, 23 | US8822505, 24)
Affinity DataIC50:  1.34E+3nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM130419(US8822505, 21 | US8822505, 23 | US8822505, 24)
Affinity DataIC50:  2.01E+3nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM130419(US8822505, 21 | US8822505, 23 | US8822505, 24)
Affinity DataIC50:  4.56nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM130419(US8822505, 21 | US8822505, 23 | US8822505, 24)
Affinity DataIC50:  1.04nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM130419(US8822505, 21 | US8822505, 23 | US8822505, 24)
Affinity DataIC50:  0.377nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM130419(US8822505, 21 | US8822505, 23 | US8822505, 24)
Affinity DataIC50:  922nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent